Director’s Channel – April 2021

Paul Katz
Paul Katz, IONs Director

It’s been just over a year now since our world went virtual. Zoom meetings, online teaching, COVID-19 testing have all become routine. Now that people are starting to be vaccinated, I’m hopeful that by fall we can resume in-person instruction, that labs can operate at full capacity, and that conferences can be held in person. Although, it’s been great to hear talks from people all around the world, we have missed out on the casual interactions, the serendipitous discussions that lead to different ways of thinking. In fact, all of the major breaks in my career have come from interactions at conferences.

Last year, we canceled the annual UMass Interdisciplinary Neurosciences conference because of the campus shutdown. We decided not to hold a virtual conference this year because personal interactions are the heart of such a local meeting. I’m confident that we will resume the tradition in the spring of 2022 when it is safe to meet in person again.

In the meantime, we continue our great lineup of virtual neuroscience speakers in April including a Distinguished Lecture by Lynn Nadel. His book, co-authored with Nobel laureate John O’Keefe, “The Hippocampus as a Cognitive Map” has framed neuroscience research on learning and memory over the last half century. Although, it would have been nice to meet Dr. Nadel in person, I am still excited to hear his perspective on the progress made in this field.

Neuroscience Research Center Construction Approved

Artist conception of the Alfred E. Newman Neuroscience Research Center

Construction of the Alfred E. Neuman Neuroscience Research Center has been approved. This building employs Open Ergonomic Systems in Science (ANOESIS). The importance of neuroscience on the UMass campus has been recognized by its central location in the current campus pond. After extended negotiation with the wetlands protection agency, it was determined that this 10 story research building would have a more positive effect on the environment than a drainage ditch with fountains. The new building will be funded completely by sales of signature goose down vests made from the displaced Canada geese. The A.E. Neuman NRC will be hiring 7 new faculty forming a research cluster to study the neural basis of gullibility.

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UMass Neurosciences Publications – March 2021

ChangHui Pak

This month’s featured researcher is ChangHui Pak, who is an Assistant Professor in the Department of Biochemistry and Molecular Biology. Her lab investigates how cell adhesion and cell signaling guides synaptic connectivity in the developing human brain with the ultimate goal of understanding how synaptic dysfunction arising from genetic mutations in synaptic molecules contributes to neuropsychiatric disorders. She has two publications appearing in PubMed this month, one is a review of Neurexin gene variation and the other is a primary research paper in collaboration with Yubing Sun from Mechanical and Industrial Engineering that reports about the development of a new device that creates a local chemical microenvironment for engineering organotypic structures in vitro. This work arose from an IONs seed grant.

Here’s what else is new for ‘ ”University of Massachusetts” AND Amherst AND neuroscience’ in PubMed. These publications appeared on line in March. They are just a fraction of the neuroscience research that occurs on campus. You can click on the PubMed ID to find the publication.

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Mélise Edwards awarded Ford Foundation Fellowship

Mélise Edwards

Mélise Edwards, 2nd year student in the Lacreuse lab (co-advised by Courtney Babbitt), received a prestigious Ford Foundation Predoctoral Fellowship, which will support 3 years of her PhD research. This competitive fellowship, funded through the National Academies of Sciences, Engineering and Medicine, supports individuals “who can demonstrate superior academic achievement, are committed to a career in teaching and research at the college or university level, show promise of future achievement as scholars and teachers, and are well prepared to use diversity as a resource for enriching the education of all students”.

Her research will compare gene expression in specific brain regions in marmosets treated with an aromatase inhibitor (Letrozole) compared to marmosets treated with a placebo. Aromatase inhibitors are commonly administered to women with estrogen-responsive breast cancers because they suppress estrogen synthesis. Unfortunately, they are also associated with cognitive dysfunction, sleep disturbances and mood disorders and little is known about the underlying mechanisms.

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