UMass Neurosciences Publications – Summer 2023

ChangHui Pak

This summer’s featured Researcher in Dr. ChangHui Pak, who is an Assistant Professor in the Department of Biochemistry and Molecular Biology. She has joined UMass in 2018 after completing postdoctoral research in the lab of Nobel laureate, Thomas Sudhof. The Pak Lab studies the molecular signaling pathways involved in synapse formation. One of the techniques that they use is the creation of brain organoids from induced Pluripotent Stem Cells (iPSCs). She was recently senior author on a Book Chapter titled, “Method to Generate Dorsal Forebrain Brain Organoids from Human Pluripotent Stem Cells” published in Stem Cell-Based Neural Model Systems for Brain Disorders.

Here’s what else is new for ‘ ”University of Massachusetts” AND Amherst AND neuroscience’ in PubMed. These publications appeared online from May to August. They are just a fraction of the neuroscience research that occurs on campus. You can click on the PubMed ID to find the publication.

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UMass Neurosciences Publications – April 2023

Alexander Surovov

This month’s featured researcher is Alexander Suvorov, who is an Associate Professor of Environmental Health Sciences and the Graduate Program Director of Environmental Health Sciences in the School of Public Health and Health Sciences. Alexander is also an associate member of the Neuroscience & Behavior Graduate program. His lab studies environmental endocrine disruptors that have the ability to interfere with endogenous hormonal signaling. Exposure to these substances during critical periods of prenatal or neonatal life may cause permanent reprogramming of target tissues, likely epigenetic in nature, which often do not present immediate phenotypes but can ultimately lead to adulthood onset diseases. He is a co-author on a review article that appeared recently in Human Reproduction Update titled, “Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development“. This work dovetails with a recent NSB seminar by Bianca Marlin on transgenerational transmission of information. It also resonates with the theme of the Neuroscience of Aging for the May 3st Interdisciplinary Neurosciences Conference

Here’s what else is new for ‘ ”University of Massachusetts” AND Amherst AND neuroscience’ in PubMed. These publications appeared online in April. They are just a fraction of the neuroscience research that occurs on campus. You can click on the PubMed ID to find the publication.

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Student Spotlight – Hui Wei

Hui Wei is a third-year Computer Science PhD student in the Manning College of Information and Computer Sciences, where he works under supervision of Prof. Benjamin Marlin in the Robust and Efficient Machine Learning (REML) lab. His research interest is applying machine learning to improving human health. Currently, he is working on machine learning for mobile health and the missing value problem in the time series data. Previously, Hui was working on evaluating the clinical diagnostic accuracy of dementia subtypes, with Prof. Narges Razavian in the Department of Population Health, NYU Grossman School of Medicine.

His recent publication in Frontiers in Aging Neuroscience compares the diagnosis in the clinic with autopsy results on Alzheimer’s disease, Lewy body disease and their combination with respect to different Clinical Dementia Rating stages. They demonstrate the diagnosis of these dementia subtypes is inaccurate and also suffers from the significant disparity in race and sex.

UMass Neurosciences Publications – March 2023

Lucy Xiaolu Wang

This month’s featured researcher is Dr. Lucy Xiaolu Wang. Lucy is an Assistant Professor in the Department of Resource Economics in the College of Social and Behavioral Sciences. She is also a Faculty Research Fellow at the Max Planck Institute for Innovation and Competition in Germany and a Faculty Associate at the Canadian Centre for Health Economics. In March, she and a collaborator published an article in The Conversation, describing her economic analysis published in PLoSOne of the Human Brain Project (HBP), a controversial $1.3 billlion European initiative that was originally led by Henry Markham. They examined the user interactions on the HBP public-access online forum to determine the value of online collaborative platforms.

Here’s what else is new for ‘ ”University of Massachusetts” AND Amherst AND neuroscience’ in PubMed. These publications appeared online in March. They are just a fraction of the neuroscience research that occurs on campus. You can click on the PubMed ID to find the publication.

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Undergraduate Student Spotlight – Yesha Patel

Yesha Patel is a senior Biochemistry & Molecular Biology and Economics dual degree undergraduate student as well as a member of the Commonwealth Honors College at the University of Massachusetts Amherst. On campus, Yesha has been a TA in the Biology department for the last two years and is in the Minutemen Equity Fund. Since she was a sophomore, Yesha has been working summers in Dr. Ella Zeldich’s lab at Boston University’s School of Medicine. She is an author on a paper that was recently published in the International Journal of Molecular Sciences, titled “Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome

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George Santos Lecture

Dr. G. Santos

April 1, 2023 – UMass Neuroscience alum and McDonald’s Genius Award Winner, George Santos will be delivering the annual Laurel and Hardy Lecture in McGuirk Stadium. The title of his talk will be “The neural basis of confabulation”. Dr. Santos is well known for his discovery of the polio vaccine, his invention of the pipette, and his sequencing of the human proteome.

His more recent work has shown how humans are susceptible to false beliefs if uttered by someone who really believes them. Santos will be giving his lecture while immersed in a tank of sharks and playing a fiddle.

UMass Neurosciences Publications – Winter 2023

Benjamin Marlin

This month’s featured researcher in Benjamin Marlin. Ben is an Associate Professor in the Manning College of Information and Computer Science, where he directs the Robust and Efficient Machine Learning (REML) group. Their work is s research is informed by real-world applications including clinical and mobile health. He was an author on paper that was published in January in the Journal Translational Behavioral Medicine, which describes some of the efforts of the Intensive Longitudinal Health Behaviors Network (ILHBN) to harmonize data collection across many different studies and data streams. Ben is also and Associate Director of the Massachusetts AI & Technology Center for Connected Care in Aging & Alzheimer’s Disease (MassAITC), which fosters the development of artificial intelligence for technology that support healthy aging at home for older adults and individuals with Alzheimer’s disease.

Here’s what else is new for ‘ ”University of Massachusetts” AND Amherst AND neuroscience’ in PubMed. These publications appeared online in January and February. They are just a fraction of the neuroscience research that occurs on campus. You can click on the PubMed ID to find the publication.

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UMass Neurosciences Publications – December 2022

Gerald Downes

This month’s featured researcher is Dr. Gerald Downes, who is an Associate Professor in the Department of Biology. His lab uses zebrafish to understand how genes and neural networks in the brain and spinal cord control movement. They are also studying mechanisms that contribute to epilepsy with the hope of developing new therapeutics to treat these disorders. He and his PhD students are authors on a paper titled, “Amyotrophic Lateral Sclerosis-Associated Persistent Organic Pollutant cis-Chlordane Causes GABAA-Independent Toxicity to Motor Neurons, Providing Evidence toward an Environmental Component of Sporadic Amyotrophic Lateral Sclerosis“, which appeared this month in Chemical Neuroscience. This work was a collaboration with researchers at Wesleyan University.

Here’s what else is new for ‘ ”University of Massachusetts” AND Amherst AND neuroscience’ in PubMed. These publications appeared online in December. They are just a fraction of the neuroscience research that occurs on campus. You can click on the PubMed ID to find the publication.

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UMass Neurosciences Publications – November 2022

Dr. Agnès Lacreuse

This month’s featured research is Dr. Agnès Lacreuse. Agnès is a Professor in the Department Psychological & Brain Sciences. Her work is focused on age-related cognitive decline in a nonhuman primate with a short lifespan, the common marmoset (C. jacchus). Research from her lab recently appeared in the journal, Hormones and Behavior, showing that Letrozole, an aromatase inhibitor used in breast cancer treatment, alters gene expression in neurons of the hippocampus, a region of the brain involved with memory. The first author on this intriguing study was Melise Edwards, a PhD student in the Neuroscience and Behavior Graduate Program.

Here’s what else is new for ‘ ”University of Massachusetts” AND Amherst AND neuroscience’ in PubMed. These publications appeared online in November. They are just a fraction of the neuroscience research that occurs on campus. You can click on the PubMed ID to find the publication.

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UMass Neurosciences Publications – October 2022

Dr. Rebecca Spencer

This month’s featured researcher is Dr. Rebecca Spencer. Bekki is a Professor in the Department of Psychological & Brain Sciences, where she runs the Somneurolab, dedicated to studying the neuroscience of sleep. She recently authored a publication in the Proceedings of the National Academy of Sciences, titled, “Contributions of memory and brain development to the bioregulation of naps and nap transitions in early childhood” in which she and her co-author, Tracy Riggins propose that nap transitions are more related to hippocampal development than age specifically. The story has received a lot of attention in the press, including the Boston Globe. You can read about it from the College of Natural Sciences.

Here’s what else is new for ‘ ”University of Massachusetts” AND Amherst AND neuroscience’ in PubMed. These publications appeared online in October. They are just a fraction of the neuroscience research that occurs on campus. You can click on the PubMed ID to find the publication.

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