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Search our RNA-seq data here (E0.5 through E7.5)
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We have characterized a large number of mutant alleles generated by the Knock-out Mouse Consortium (KOMP2) that have lethal phenotypes occurring before E9.5. Thus far we have analyzed more than 200 distinct knockout lines produced by the Knock Out Mouse Project. Here we provide data summarizing each early lethal mutant phenotype. More information about the international effort to understand the function of all protein coding genes available on the International Mouse Phenotyping Consortium website. We find approximately half of homozygous knockout embryos can be recovered at E7.5 but arrest prior to gastrulation. The other half cannot be found at E7.5 but are recovered during preimplantation stages with ~25% arresting/dying prior to blastocyst formation while the other ~25% form normal blastocysts but fail to implant. To our knowledge this is the first systematic study of early lethal knockouts conducted using similar mutation strategies on the same genetic background (C57Bl/6JN). Summary data for each phenotype available below. Full data sets and information available by contacting Dr. Jesse Mager (jmager@umass.edu).
2310011J03Rik

4933427D14Rik

Aagab

Aars1

Aasdhppt

Aatf

Actr8

Afg2b

Alg14

Anln

Ap2s1

Atp2b1

Atp5d

Atp6v1f

B4gat1

Banf1

Bcs1l

Borcs6

Click HERE for our recent paper “Borcs6 is required for endo-lysosomal degradation during early development.”
Casc3

Ccdc59

Ccdc93

Cct7

Cct8

Cdc37

Cdin1

Cenpo

Cherp

Clptm1

Clpx

Cog1

Coq5

Cyc1

Dbr1

Dctn6

Ddx10

Ddx18

Ddx21

Ddx46

Ddx47

Ddx59

Dhx8

Dhx15

Dhx37

Dimt1

Dmxl1

Dnaaf2

Click HERE for our recent paper “A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia.”
Dnaaf5

Dnajc13

Dolk

Ebna1bp2

Efl1

Eif2s1

Eif3e

Eif5b

Eipr1

Elof1

Click HERE for our recent paper “The elongation factor Elof1 is required for mammalian gastrulation.”
Eny2

Exoc2

Exosc1

Click HERE for our recent paper “Exosome complex components 1 and 2 are vital for early mammalian development.”
Exosc2

Click HERE for our recent paper “Exosome complex components 1 and 2 are vital for early mammalian development.”
Exosc7

Fastkd5

Gemin6

Glrx3

Gpn1

Gspt1

Gtpbp4

Hars2

Haus4

Hlcs

Ipo11

Ipo7

Isca1

Isy1

Kansl3

Click HERE for our recent paper “Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality.”
Lin52

Lsm2

Ltv1

Mars1

Mars2

Mbip

Mcrs1

Click HERE for our recent paper “MCRS1 is essential for epiblast development during early mouse embryogenesis.”
Med20

Click HERE for our recent paper “Med20 is essential for early embryogenesis and regulates Nanog expression.”
Mepce

Mob4

Mrm3

Mrpl22

Mrpl3

Mrpl39

Mrpl41

Mrpl44

Mrpl53

Mrps18c

Mrps22

Mrps25

Mtpap

Mtx2

Naa20

Nars1

Nars2

Ncapd3

Ndc80

Ndufa9

Ndufa11

Ndufs8

Nifk

Nsl1

Nup155

Nup205

Nup54

Nup93

Orc2

Orc6

Osbp

Pdcd7

Pkm

Pmpcb

Pold2

Click HERE for our recent paper “Early embryonic lethality of mice lacking POLD2.”
Polr1a

Polr1d

Click HERE for our recent paper “Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice.”
Polr2b

Polr2e

Polr2j

Pop5

Ppp1r35

Click HERE for our recent paper “Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.”
Prim1

Prpf4b

Pum3

Rab11a

Rad54l2

Ramac

Ranbp2

Rbbp4

Click HERE for our recent paper “Loss of RBBP4 results in defective inner cell mass, severe apoptosis, hyperacetylated histones and preimplantation lethality in mice.”
Riok1

Rpain

Rps27

Ruvbl2

Sars1

Sart3

Scfd1

Sdhaf2

Sec16a

Sec61g

Sepsecs

Ska2

Skic3

Smarce1

Snapc2

Snrnp40

Snrnp70

Sptb

Sptssa

Srfbp1

Strn3

Taf5

Click HERE for our recent paper “TATA-binding associated factors have distinct roles during early mammalian development.”
Taf12

Click HERE for our recent paper “TATA-binding associated factors have distinct roles during early mammalian development.”
Taf13

Click HERE for our recent paper “TATA-binding associated factors have distinct roles during early mammalian development.”
Taf1a

Taf1c

Taf1d

Tbcb

Tbcc

Tbcd

Thoc3

Thoc7

Ticrr

Timm22

Tmx2

Tomm20

Tomm70a

Tpk1

Trit1

Trmt5

Tsen54

Ttc1

Ttc4

Tti1

Ttk

Tubgcp2

Tubgcp4

U2af2

Ube2m

Uqcr10

Utp4

Washc4

Wdr25

Wdr73

Ykt6

Ylpm1

Zc3h4

Click HERE for our recent paper “ZC3H4—a novel Cys-Cys-Cys-His-type zinc finger protein—is essential for early embryogenesis in mice.”
Zfp407

Zfp622

Znhit1

Click HERE for our recent paper “Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development.”
Znhit2

Click HERE for our recent paper “Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development.”
Zwint
