Phenotypes of Novel IMPC Alleles

Click here to see the IMPC website

(SCROLL DOWN THROUGH ALL GENE SPECIFIC DATA)

Take a look at our Recent Publications

Search our RNA-seq data here (E0.5 through E7.5)

Visit our Mager Lab Website

We have characterized a large number of mutant alleles generated by the Knock-out Mouse Consortium (KOMP2) that have lethal phenotypes occurring before E9.5. Thus far we have analyzed more than 200 distinct  knockout lines produced by the Knock Out Mouse Project. Here we provide data summarizing each early lethal mutant phenotype. More information about the international effort to understand the function of all protein coding genes available on the International Mouse Phenotyping Consortium website.  We find approximately half of homozygous knockout embryos can be recovered at E7.5 but arrest prior to gastrulation.  The other half cannot be found at E7.5 but are recovered during preimplantation stages with ~25% arresting/dying prior to blastocyst formation while the other ~25% form normal blastocysts but fail to implant. To our knowledge this is the first systematic study of early lethal knockouts conducted using similar mutation strategies on the same genetic background (C57Bl/6JN).  Summary data for each phenotype available below. Full data sets and information available by contacting Dr. Jesse Mager (jmager@umass.edu).

 

2310011J03Rik

knock out mouse embryo 2310011J03Rik gastrulation

IMPC data for 2310011J03Rik

MGI data for 2310011J03Rik

4933427D14Rik

IMPC data for 4933427D14Rik

MGI data for 4933427D14Rik

Aagab

knock out mouse embryo Aagab gastrulation

IMPC data for Aagab

MGI data for Aagab

OMIM data for Aagab

Aars1

knock out mouse embryo Aars1 Aars preimplantation

IMPC data for Aars1

MGI data for Aars1

OMIM data for Aars1

Aasdhppt

IMPC data for Aasdhppt

MGI data for Aasdhppt

OMIM data for Aasdhppt

Aatf

IMPC data for Aatf

MGI data for Aatf

OMIM data for Aatf

Actr8

IMPC data for Actr8

MGI data for Actr8

OMIM data for Actr8

Afg2b

knock out mouse embryo Afg2b preimplantation

IMPC data for Afg2b

MGI data for Afg2b

OMIM data for Afg2b

Alg14

IMPC data for Alg14

MGI data for Alg14

OMIM data for Alg14

Anln

IMPC data for Anln

MGI data for Anln

OMIM data for Anln

Ap2s1

IMPC data for Ap2s1

MGI data for Ap2s1

OMIM data for Ap2s1

Atp2b1

IMPC data for Atp2b1

MGI data for Atp2b1

OMIM data for Atp2b1

Atp5d

IMPC data for Atp5f1d

MGI data for Atp5f1d

OMIM data for Atp5f1d

Atp6v1f

IMPC data for Atp6v1f

MGI data for Atp6v1f

OMIM data for Atp6v1f

B4gat1

IMPC data for B4gat1

MGI data for B4gat1

OMIM data for B4gat1

Banf1

IMPC data for Banf1

MGI data for Banf1

OMIM data for Banf1

Bcs1l

IMPC data for Bcs1l

MGI data for Bcs1l

OMIM data for Bcs1l

Borcs6

Click HERE for our recent paper “Borcs6 is required for endo-lysosomal degradation during early development.”

IMPC data for Borcs6

MGI data for Borcs6

OMIM data for Borcs6

Casc3

IMPC data for Casc3

MGI data for Casc3

OMIM data for Casc3

Ccdc59

IMPC data for Ccdc59

MGI data for Ccdc59

OMIM data for Ccdc59

Ccdc93

IMPC data for Ccdc93

MGI data for Ccdc93

OMIM data for Ccdc93

Cct7

knock out mouse embryo Cct7 preimplantation

IMPC data for Cct7

MGI data for Cct7

OMIM data for Cct7

Cct8

IMPC data for Cct8

MGI data for Cct8

OMIM data for Cct8

Cdc37

IMPC data for Cdc37

MGI data for Cdc37

OMIM data for Cdc37

Cdin1

IMPC data for Cdin1

MGI data for Cdin1

Cenpo

IMPC data for Cenpo

MGI data for Cenpo

OMIM data for Cenpo

Cherp

IMPC data for Cherp

MGI data for Cherp

OMIM data for Cherp

Clptm1

IMPC data for Clptm1

MGI data for Clptm1

OMIM data for Clptm1

Clpx

IMPC data for Clpx

MGI data for Clpx

OMIM data for Clpx

Cog1

knock out mouse embryo Cog1 preimplantation

IMPC data for Cog1

MGI data for Cog1

OMIM data for Cog1

Coq5

knock out mouse embryo Coq5 gastrulation

IMPC data for Coq5

MGI data for Coq5

OMIM data for Coq5

Cyc1

IMPC data for Cyc1

MGI data for Cyc1

OMIM data for Cyc1

Dbr1

IMPC data for Dbr1

MGI data for Dbr1

OMIM data for Dbr1

Dctn6

IMPC data for Dctn6

MGI data for Dctn6

OMIM data for Dctn6

Ddx10

IMPC data for Ddx10

MGI data for Ddx10

OMIM data for Ddx10

Ddx18

knock out mouse embryo Ddx18 preimplantation

IMPC data for Ddx18

MGI data for Ddx18

OMIM data for Ddx18

Ddx21

IMPC data for Ddx21

MGI data for Ddx21

OMIM data for Ddx21

Ddx46

IMPC data for Ddx46

MGI data for Ddx46

OMIM data for Ddx46

Ddx47

IMPC data for Ddx47

MGI data for Ddx47

OMIM data for Ddx47

Ddx59

IMPC data for Ddx59

MGI data for Ddx59

OMIM data for Ddx59

Dhx8

IMPC data for Dhx8

MGI data for Dhx8

OMIM data for Dhx8

Dhx15

knock out mouse embryo Dhx15 preimplantation

IMPC data for Dhx15

MGI data for Dhx15

OMIM data for Dhx15

Dhx37

IMPC data for Dhx37

MGI data for Dhx37

OMIM data for Dhx37

Dimt1

knock out mouse embryo preimplantation Dimt1

IMPC data for Dimt1

MGI data for Dimt1

OMIM data for Dimt1

Dmxl1

knock out mouse embryo Dmxl1 gastrulation

IMPC data for Dmxl1

MGI data for Dmxl1

OMIM data for Dmxl1

Dnaaf2

Click HERE for our recent paper “A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia.”

IMPC data for Dnaaf2

MGI data for Dnaaf2

OMIM data for Dnaaf2

Dnaaf5

knock out mouse embryo gastulation Dnaaf5

IMPC data for Dnaaf5

MGI data for Dnaaf5

OMIM data for Dnaaf5

Dnajc13

IMPC data for Dnajc13

MGI data for Dnajc13

OMIM data for Dnajc13

Dolk

IMPC data for Dolk

MGI data for Dolk

OMIM data for Dolk

Ebna1bp2

IMPC data for Ebna1bp2

MGI data for Ebna1bp2

OMIM data for Ebna1bp2

Efl1

IMPC data for Efl1

MGI data for Efl1

OMIM data for Efl1

Eif2s1

knock out mouse embryo Eif2s1 preimplantation

IMPC data for Eif2s1

MGI data for Eif2s1

OMIM data for Eif2s1

Eif3e

knock out mouse embryo Eif3e preimplantation

IMPC data for Eif3e

MGI data for Eif3e

OMIM data for Eif3e

Eif5b

IMPC data for Eif5b

MGI data for Eif5b

OMIM data for Eif5b

Eipr1

IMPC data for Eipr1

MGI data for Eipr1

OMIM data for Eipr1

Elof1

Click HERE for our recent paper “The elongation factor Elof1 is required for mammalian gastrulation.”

IMPC data for Elof1

MGI data for Elof1

OMIM data for Elof1

Eny2

IMPC data for Eny2

MGI data for Eny2

OMIM data for Eny2

Exoc2

IMPC data for Exoc2

MGI data for Exoc2

OMIM data for Exoc2

Exosc1

knock out mouse embryo Exosc1 gastrulation

Click HERE for our recent paper “Exosome complex components 1 and 2 are vital for early mammalian development.”

IMPC data for Exosc1

MGI data for Exosc1

OMIM data for Exosc1

Exosc2

knock out mouse embryo Exosc2 preimplantation

Click HERE for our recent paper “Exosome complex components 1 and 2 are vital for early mammalian development.”

IMPC data for Exosc2

MGI data for Exosc2

OMIM data for Exosc2

Exosc7

IMPC data for Exosc7

MGI data for Exosc7

OMIM data for Exosc7

Fastkd5

IMPC data for Fastkd5

MGI data for Fastkd5

OMIM data for Fastkd5

Gemin6

IMPC data for Gemin6

MGI data for Gemin6

OMIM data for Gemin6

Glrx3

IMPC data for Glrx3

MGI data for Glrx3

OMIM data for Glrx3

Gpn1

knock out mouse embryo Gpn1 preimplantation

IMPC data for Gpn1

MGI data for Gpn1

OMIM data for Gpn1

Gspt1

knock out mouse embryo Gspt1 preimplantation

IMPC data for Gspt1

MGI data for Gspt1

OMIM data for Gspt1

Gtpbp4

IMPC data for Gtpbp4

MGI data for Gtpbp4

OMIM data for Gtpbp4

Hars2

knock out mouse embryo Hars2 gastrulation

IMPC data for Hars2

MGI data for Hars2

OMIM data for Hars2

Haus4

IMPC data for Haus4

MGI data for Haus4

OMIM data for Haus4

Hlcs

IMPC data for Hlcs

MGI data for Hlcs

OMIM data for Hlcs

Ipo11

IMPC data for Ipo11

MGI data for Ipo11

OMIM data for Ipo11

Ipo7

IMPC data for Ipo7

MGI data for Ipo7

OMIM data for Ipo7

Isca1

IMPC data for Isca1

MGI data for Isca1

OMIM data for Isca1

Isy1

IMPC data for Isy1

MGI data for Isy1

OMIM data for Isy1

Kansl3

knock out mouse embryo preimplantation Kansl3

Click HERE for our recent paper “Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality.”

IMPC data for Kansl3

MGI data for Kansl3

OMIM data for Kansl3

Lin52

IMPC data for Lin52

MGI data for Lin52

Lsm2

IMPC data for Lsm2

MGI data for Lsm2

OMIM data for Lsm2

Ltv1

IMPC data for Ltv1

MGI data for Ltv1

OMIM data for Ltv1

Mars1

knock out mouse embryo Mars1 preimplantation

IMPC data for Mars1

MGI data for Mars1

OMIM data for Mars1

Mars2

IMPC data for Mars2

MGI data for Mars2

OMIM data for Mars2

Mbip

IMPC data for Mbip

MGI data for Mbip

OMIM data for Mbip

Mcrs1

Click HERE for our recent paper “MCRS1 is essential for epiblast development during early mouse embryogenesis.”

IMPC data for Mcrs1

MGI data for Mcrs1

OMIM data for Mcrs1

Med20

Click HERE for our recent paper “Med20 is essential for early embryogenesis and regulates Nanog expression.”

IMPC data for Med20

MGI data for Med20

OMIM data for Med20

Mepce

IMPC data for Mepce

MGI data for Mepce

OMIM data for Mepce

Mob4

knock out mouse embryo Mob4 gastrulation

IMPC data for Mob4

MGI data for Mob4

OMIM data for Mob4

Mrm3

IMPC data for Mrm3

MGI data for Mrm3

OMIM data for Mrm3

Mrpl22

IMPC data for Mrpl22

MGI data for Mrpl22

OMIM data for Mrpl22

Mrpl3

IMPC data for Mrpl3

MGI data for Mrpl3

OMIM data for Mrpl3

Mrpl39

knock out mouse embryo Mrpl39 gastrulation

IMPC data for Mrpl39

MGI data for Mrpl39

OMIM data for Mrpl39

Mrpl41

IMPC data for Mrpl41

MGI data for Mrpl41

OMIM data for Mrpl41

Mrpl44

IMPC data for Mrpl44

MGI data for Mrpl44

OMIM data for Mrpl44

Mrpl53

knock out mouse embryo Mrpl53 gastrulation

IMPC data for Mrpl53

MGI data for Mrpl53

OMIM data for Mrpl53

Mrps18c

IMPC data for Mrps18c

MGI data for Mrps18c

OMIM data for Mrps18c

Mrps22

IMPC data for Mrps22

MGI data for Mrps22

OMIM data for Mrps22

Mrps25

IMPC data for Mrps25

MGI data for Mrps25

OMIM data for Mrps25

Mtpap

IMPC data for Mtpap

MGI data for Mtpap

OMIM data for Mtpap

Mtx2

IMPC data for Mtx2

MGI data for Mtx2

OMIM data for Mtx2

Naa20

knock out mouse embryo Naa20 preimplantation

IMPC data for Naa20

MGI data for Naa20

OMIM data for Naa20

Nars1

IMPC data for Nars1

MGI data for Nars1

OMIM data for Nars1

Nars2

IMPC data for Nars2

MGI data for Nars2

OMIM data for Nars2

Ncapd3

IMPC data for Ncapd3

MGI data for Ncapd3

OMIM data for Ncapd3

Ndc80

IMPC data for Ndc80

MGI data for Ndc80

OMIM data for Ndc80

Ndufa9

IMPC data for Ndufa9

MGI data for Ndufa9

OMIM data for Ndufa9

Ndufa11

knock out mouse embryo Ndufa11 gastrulation

IMPC data for Ndufa11

MGI data for Ndufa11

OMIM data for Ndufa11

Ndufs8

IMPC data for Ndufs8

MGI data for Ndufs8

OMIM data for Ndufs8

Nifk

IMPC data for Nifk

MGI data for Nifk

OMIM data for Nifk

Nsl1

IMPC data for Nsl1

MGI data for Nsl1

OMIM data for Nsl1

Nup155

IMPC data for Nup155

MGI data for Nup155

OMIM data for Nup155

Nup205

IMPC data for Nup205

MGI data for Nup205

OMIM data for Nup205

Nup54

IMPC data for Nup54

MGI data for Nup54

OMIM data for Nup54

Nup93

IMPC data for Nup93

MGI data for Nup93

OMIM data for Nup93

Orc2

IMPC data for Orc2

MGI data for Orc2

OMIM data for Orc2

Orc6

IMPC data for Orc6

MGI data for Orc6

OMIM data for Orc6

Osbp

IMPC data for Osbp

MGI data for Osbp

OMIM data for Osbp

Pdcd7

IMPC data for Pdcd7

MGI data for Pdcd7

OMIM data for Pdcd7

Pkm

knock out mouse embryo Pkm gastrulation

IMPC data for Pkm

MGI data for Pkm

OMIM data for Pkm

Pmpcb

IMPC data for Pmpcb

MGI data for Pmpcb

OMIM data for Pmpcb

Pold2

Click HERE for our recent paper “Early embryonic lethality of mice lacking POLD2.

IMPC data for Pold2

MGI data for Pold2

OMIM data for Pold2

Polr1a

IMPC data for Polr1a

MGI data for Polr1a

OMIM data for Polr1a

Polr1d

Click HERE for our recent paper “Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice.”

IMPC data for Polr1d

MGI data for Polr1d

OMIM data for Polr1d

Polr2b

IMPC data for Polr2b

MGI data for Polr2b

OMIM data for Polr2b

Polr2e

knock out mouse embryo Polr2e preimplantation

IMPC data for Polr2e

MGI data for Polr2e

OMIM data for Polr2e

Polr2j

knock out mouse embryo Polr2j

IMPC data for Polr2j

MGI data for Polr2j

OMIM data for Polr2j

Pop5

IMPC data for Pop5

MGI data for Pop5

OMIM data for Pop5

Ppp1r35

Click HERE for our recent paper “Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.”

IMPC data for Ppp1r35

MGI data for Ppp1r35

OMIM data for Ppp1r35

Prim1

IMPC data for Prim1

MGI data for Prim1

OMIM data for Prim1

Prpf4b

IMPC data for Prpf4b

MGI data for Prpf4b

OMIM data for Prpf4b

Pum3

knock out mouse embryo Pum3 preimplantation

IMPC data for Pum3

MGI data for Pum3

OMIM data for Pum3

Rab11a

IMPC data for Rab11a

MGI data for Rab11a

OMIM data for Rab11a

Rad54l2

IMPC data for Rad54l2

MGI data for Rad54l2

OMIM data for Rad54l2

Ramac

IMPC data for Ramac

MGI data for Ramac

OMIM data for Ramac

Ranbp2

IMPC data for Ranbp2

MGI data for Ranbp2

OMIM data for Ranbp2

Rbbp4

Click HERE for our recent paper “Loss of RBBP4 results in defective inner cell mass, severe apoptosis, hyperacetylated histones and preimplantation lethality in mice.”

IMPC data for Rbbp4

MGI data for Rbbp4

OMIM data for Rbbp4

Riok1

IMPC data for Riok1

MGI data for Riok1

OMIM data for Riok1

Rpain

IMPC data for Rpain

MGI data for Rpain

OMIM data for Rpain

Rps27

IMPC data for Rps27

MGI data for Rps27

OMIM data for Rps27

Ruvbl2

knock out mouse embryo Ruvbl2 preimplantation

IMPC data for Ruvbl2

MGI data for Ruvbl2

OMIM data for Ruvbl2

Sars1

IMPC data for Sars1

MGI data for Sars1

OMIM data for Sars1

Sart3

IMPC data for Sart3

MGI data for Sart3

OMIM data for Sart3

Scfd1

IMPC data for Scfd1

MGI data for Scfd1

OMIM data for Scfd1

Sdhaf2

IMPC data for Sdhaf2

MGI data for Sdhaf2

OMIM data for Sdhaf2

Sec16a

knock out mouse embryo Sec16a preimplantation

IMPC data for Sec16a

MGI data for Sec16a

OMIM data for Sec16a

Sec61g

knock out mouse embryo Sec61g preimplantation

IMPC data for Sec61g

MGI data for Sec61g

OMIM data for Sec61g

Sepsecs

IMPC data for Sepsecs

MGI data for Sepsecs

OMIM data for Sepsecs

Ska2

IMPC data for Ska2

MGI data for Ska2

OMIM data for Ska2

Skic3

knock out mouse embryo Skic3 gastrulation

IMPC data for Skic3

MGI data for Skic3

OMIM data for Skic3

Smarce1

IMPC data for Smarce1

MGI data for Smarce1

OMIM data for Smarce1

Snapc2

IMPC data for Snapc2

MGI data for Snapc2

OMIM data for Snapc2

Snrnp40

IMPC data for Snrnp40

MGI data for Snrnp40

OMIM data for Snrnp40

Snrnp70

IMPC data for Snrnp70

MGI data for Snrnp70

OMIM data for Snrnp70

Sptb

IMPC data for Sptb

MGI data for Sptb

OMIM data for Sptb

Sptssa

IMPC data for Sptssa

MGI data for Sptssa

OMIM data for Sptssa

Srfbp1

knock out mouse embryo Srfbp1 preimplantation

IMPC data for Srfbp1

MGI data for Srfbp1

OMIM data for Srfbp1

 Strn3

IMPC data for Strn3

MGI data for Strn3

OMIM data for Strn3

Taf5

knock out mouse embryo Taf5 preimplantation

Click HERE for our recent paper “TATA-binding associated factors have distinct roles during early mammalian development.”

IMPC data for Taf5

MGI data for Taf5

OMIM data for Taf5

Taf12

knock out mouse embryo Taf12 preimplantation

Click HERE for our recent paper “TATA-binding associated factors have distinct roles during early mammalian development.”

IMPC data for Taf12

MGI data for Taf12

OMIM data for Taf12

Taf13

knock out mouse embryo Taf13 gastrulation

Click HERE for our recent paper “TATA-binding associated factors have distinct roles during early mammalian development.”

IMPC data for Taf13

MGI data for Taf13

OMIM data for Taf13

Taf1a

knock out mouse embryo Taf1a

IMPC data for Taf1a

MGI data for Taf1a

OMIM data for Taf1a

Taf1c

IMPC data for Taf1c

MGI data for Taf1c

OMIM data for Taf1c

Taf1d

IMPC data for Taf1d

MGI data for Taf1d

OMIM data for Taf1d

Tbcb

IMPC data for Tbcb

MGI data for Tbcb

OMIM data for Tbcb

Tbcc

IMPC data for Tbcc

MGI data for Tbcc

OMIM data for Tbcc

Tbcd

IMPC data for Tbcd

MGI data for Tbcd

OMIM data for Tbcd

Thoc3

IMPC data for Thoc3

MGI data for Thoc3

OMIM data for Thoc3

Thoc7

IMPC data for Thoc7

MGI data for Thoc7

OMIM data for Thoc7

Ticrr

knock out mouse embryo Ticrr preimplantation

IMPC data for Ticrr

MGI data for Ticrr

OMIM data for Ticrr

Timm22

IMPC data for Timm22

MGI data for Timm22

OMIM data for Timm22

Tmx2

IMPC data for Tmx2

MGI data for Tmx2

OMIM data for Tmx2

Tomm20

IMPC data for Tomm20

MGI data for Tomm20

OMIM data for Tomm20

Tomm70a

knock out mouse embryo Tomm70a gastrulation

IMPC data for Tomm70a

MGI data for Tomm70a

OMIM data for Tomm70a

Tpk1

IMPC data for Tpk1

MGI data for Tpk1

OMIM data for Tpk1

Trit1

IMPC data for Trit1

MGI data for Trit1

OMIM data for Trit1

Trmt5

IMPC data for Trmt5

MGI data for Trmt5

OMIM data for Trmt5

Tsen54

IMPC data for Tsen54

MGI data for Tsen45

OMIM data for Tsen54

Ttc1

IMPC data for Ttc1

MGI data for Ttc1

OMIM data for Ttc1

Ttc4

knock out mouse embryo Ttc4 preimplantation

IMPC data for Ttc4

MGI data for Ttc4

OMIM data for Ttc4

Tti1

knock out mouse embryo Tti1 preimplantation

IMPC data for Tti1

MGI data for Tti1

OMIM data for Tti1

Ttk

IMPC data for Ttk

MGI data for Ttk

OMIM data for Ttk

Tubgcp2

IMPC data for Tubgcp2

MGI data for Tubgcp2

OMIM data for Tubgcp2

Tubgcp4

IMPC data for Tubgcp4

MGI data for Tubgcp4

OMIM data for Tubgcp4

U2af2

IMPC data for U2af2

MGI data for U2af2

OMIM data for U2af2

Ube2m

IMPC data for Ube2m

MGI data for Ube2m

OMIM data for Ube2m

Uqcr10

IMPC data for Uqcr10

MGI data for Uqcr10

OMIM data for Uqcr10

Utp4

knock out mouse embryo Utp4 preimplantation

IMPC data for Utp4

MGI data for Utp4

OMIM data for Utp4

Washc4

IMPC data for Washc4

MGI data for Washc4

OMIM data for Washc4

Wdr25

knock out mouse embryo Wdr25 gastrulation

IMPC data for Wdr25

MGI data for Wdr25

OMIM data for Wdr25

Wdr73

IMPC data for Wdr73

MGI data for Wdr73

OMIM data for Wdr73

Ykt6

IMPC data for Ykt6

MGI data for Ykt6

OMIM data for Ykt6

Ylpm1

IMPC data for Ylpm1

MGI data for Ylpm1

OMIM data for Ylpm1

Zc3h4

Click HERE for our recent paper “ZC3H4—a novel Cys-Cys-Cys-His-type zinc finger protein—is essential for early embryogenesis in mice.”

IMPC data for Zc3h4

MGI data for Zc3h4

OMIM data for Zc3h4

Zfp407

IMPC data for Zfp407

MGI data for Zfp407

Zfp622

IMPC data for Zfp622

MGI data for Zfp622

Znhit1

knock out mouse embryo Znhit1 preimplantation

Click HERE for our recent paper “Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development.”

IMPC data for Znhit1

MGI data for Znhit1

OMIM data for Znhit1

Znhit2

knock out mouse embryo Znhit2 preimplantation

Click HERE for our recent paper “Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development.”

IMPC data for Znhit2

MGI data for Znhit2

OMIM data for Znhit2

 Zwint

IMPC data for Zwint

MGI data for Zwint

OMIM data for Zwint