.
Representative Publications
“Functional and analytical recapitulation of osteoclast biology on demineralized bone paper” Nature Communications
“Trabecular bone organoid model for studying the regulation of localized bone remodeling” Science Advances
“Thermoresponsive inverted colloidal crystal hydrogel scaffolds for lymphoid tissue engineering” Advanced Healthcare Materials
“In vitro reconstitution of an intestinal mucus layer shows that cations and pH control the pore structure that regulates its permeability and barrier function” ACS Applied Biomaterials
“Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells” Nature Biomedical Engineering
“Bioengineered Implantable Scaffolds as A Tool to Study Stromal-Derived Factors in Metastatic Cancer Models“ Cancer Research
“Implantable Microenvironments to Attract Hematopoietic Stem/Cancer Cells” Proceedings of the National Academic Sciences
“In vitro Toxicity Testing of Nanoparticles in Three Dimensional Cell Culture” Small
“Three-Dimensional Cell Culture Matrices: State of The Art” Tissue Engineering Part B: Review
“Inverted Colloidal Crystals Scaffolds as Three Dimensional Microenvironments for Cellular Co-cultures” Journal of Materials Chemistry
Citations: Google Scholar
2025
48. Patrick Ryan, Jungwoo Lee “In vitro senescence and senolytic functional assays“Biomaterials Science, 2025, 13: 3509.
47. Seema Amin, Hyejin Yoon, Dong-Hee Choi, Yi-Hao Hsu, Jungwoo Lee “Murine Osteoblast and Osteoclast Coculture on Demineralized Bone Paper for Bone Remodeling” Bio-protocol 2025, 15(11): e5339.
46. Jeong Min Oh, Yongkuk Park, Jungwoo Lee*, Keyue Shen* Microfabricated Organ-Specific Models of Tumor Microenvironments” Annual Reviews of Biomedical Engineering 2025, 27(1): 307.
45. Patrick Ryan, Hyejin Yoon, Seema Amin, James J Chambers, Jungwoo Lee “AI-Assisted label-free monitoring bone mineral metabolism on demineralized bone paper” ACS Biomaterials Science & Engineering 2025, 11(4): 2096. (Cover Article)
2024
44. Hyejin Yoon, Yongkuk Park, Jun-Goo Kwak, Jungwoo Lee “Collagen structures of demineralized bone paper direct mineral metabolism” Journal of Bone & Mineral Research Plus 2024, 8(8): ziae080
2023
43. Yongkuk Park, Tadatoshi Sato, Jungwoo Lee “Functional and analytical recapitulation of osteoclast biology on demineralized bone paper” Nature Communications, 2023, 14(1): 8092.
42. Jun-Goo Kwak, Jungwoo Lee Bone marrow adipocytes contribute to tumor microenvironment-driven chemoresistance via sequestration of doxorubicin” Cancers, 2023, 15(10): 2737.
2022
41. Abhinav Sharma, Vishnu Raman, Jungwoo Lee, Neil S Forbes “Microbial Imbalance Induces Inflammation by Promoting Salmonella Penetration through the Mucosal Barrier”ACS Infectious Diseases 2022:8(5): 969.
2021
40. Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, Jungwoo Lee* “Trabecular bone organoid model for studying the regulation of localized bone remodeling” Science Advances, 2021; 7: eabd6495.
2020
39. Abhinav Sharma, Vishnu Raman, Jungwoo Lee*, Neil Forbes* “Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-a and IL-8 secretion” Biotechnology and Bioengineering (2020) 117:2540-2555.
38. Abhinav Sharma, Jun-Goo Kwak, Kristopher W. Kolewe, Jessica D. Schiffman, Neil Forbes*, Jungwoo Lee* “In vitro reconstitution of an intestinal mucus layer shows that cations and pH control the pore structure that regulates its permeability and barrier function” ACS Applied Biomaterials (2020), 3 (5), 2897-2909.
37. Ryan Carpenter, Dalton Macres, Jun-Goo Kwak, Katherine Daniel, Jungwoo Lee* “Fabrication of bioactive inverted colloidal crystal scaffolds using expanded polystyrene beads” Tissue Engineering Part C: Methods (2020) 143-155. (Cover Article)
36. Jun-Goo Kwak, Jungwoo Lee* “Thermoresponsive inverted colloidal crystal hydrogel scaffolds for lymphoid tissue engineering” Advanced Healthcare Materials (2020) 1901556. (Cover Article)
2019
35. Ryan Carpenter, Hye Jeong Oh, In-Hye Ham, Daeyoung Kim, Hoon Hur, Jungwoo Lee* “Scaffold-assisted ectopic transplantation of internal organs and patient-derived tumors” ACS Biomaterials Science Engineering, 2019, 5(12), 6667. (Cover Article)
2018
34. Ryan Carpenter, Jun-Goo Kwak, Shelly Peyton, Jungwoo Lee* “Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells” Nature Biomedical Engineering 2018
(www.nature.com/articles/s41551-018-0307-x)
* Highlight: Science Translational Medicine (Charting the course of metastasis)
* Highlight: Nature Biomedical Engineering (Engineered niches model the onset of metastasis)
33. Lee J*, Heckl D, Parekkadan B.* “Multiple Genetically Engineered Humanized Microenvironments in a Single Mouse” Biomaterials Research 2016, 20:19 (* Co-Corresponding Author)
2015
32. Lee J*, Kohl N., Shanbhang S., Parekkadan B.* “Scaffold-Integrated Microchips for End-to-End In Vitro Tumor Cell Attachment and Xenograft Formation” TECHNOLOGY 2015, 3, 197 (* Co-Corresponding Author)
(Research Highlights in ScienceDaily)
31. Lee J*, Bersani F*, Yu M, Morris R, Desai R, Ramaswamy S, Toner M, Haber DA, Parekkadan B “Bioengineered Implantable Scaffolds as A Tool to Study Stromal-Derived Factors in Metastatic Cancer Models” Cancer Res (2014) 74(24) 7229-7238. (* Co-first Author)
30. Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellev A, Lee J, Bale SS, Chakraborty N, Brines M, Cerami A, Berthiaume F, Yarmush ML “Modulation of Cellular Stress Response via the Erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells” J Mol Med (2014) ASAP.
29. Shen K, Lee J, Yarmush M, Parekkadan B, “Microcavity Substrates Cased From Self-Assembled Microspher Monolayers for Spheroid Cell Culture” Biomed Microdevices (2014) 16(4): 609-615.
28. J.M. Milwid, J. Elman, M. Li, K. Shen, A. Manrai, A. Gabow, J. Yarmush, Y. Jiao, A. Fletcher, J. Lee, M. Cima, M. Yarmush, B. Parekkadan“Enriched Protein Screening of Human Bone Marrow Mesenchymal Stromal Cell Secretions Reveals MFAP5 and PENK as Novel IL-10 Modulators” Molecular Therapy (2013) 22(5): 999-1007.
27. J. Lee, J.B. Wang, F. Bersani, B. Parekkadan “Capture and Printing of Fixed Stromal Cell Membrane for Bioactive Display on PDMS Surfaces” Langmuir (2013) 29(34) 10611.
26. O.B. Usta, Y. Kim, S. Ozer, B.G. Bruinsma, J. Lee, E. Demir, T.A. Berendsen, C.F. Puts, M.L. Izamis, K. Uygun, B.E. Uygun, M.L. Yarmush “Supercooling as a viable non-freezing cell preservation method of rat hepatocytes” Plus One (2013) 8(7) e69334.
25. J.M. Milwid, M. Li, J. Jiao, J. Lee, M.L. Yarmush, and B. Parekkadan “Evidence of a Hematopoietic Origin of Human Bone Marrow Stromal Cells” Journal of Bone Marrow Research (2013) 1:113.
24. J. Milwid, T. Ichimura, M. Li, Y. Jiao, J. Lee, J. Yarmush, B. Parekkadan, A. Tilles, J.V. Bonventre and M. L. Yarmush “Secreted Factors From Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury” Stem Cells International (2012), Article ID 392050, 12 pages 2012. Doi:10.1155/2012/392050.
23. J. Lee, M. Li, J. Milwid, J. Dunham, C. Vinegoni, R. Gorbatov, Y. Iwamoto, F. Wang, K. Shen, K. Hatfield, M. Enger, S. Shafiee, E. McCormack, B. Ebert, R. Weissleder, M.L. Yarmush, B. Parekkadan “Implantable Microenvironments to Attract Hematopoietic Stem/Cancer Cells” Proceedings of the National Academic Sciences (2012) 109(48) 19638-19643.
(Research Highlights in Nature Methods)
22. Tim A. Berendsen, Bote G. Bruinsma, Jungwoo Lee, Vincent D’Andrea, Qiang Lui, Maria-Louisa Izamis, Korkut Uygun, Martin L. Yarmush “A simplified sub-normothermic machine perfusion model restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation” Transplantation Research (2012) 1:6doi:10.1186/2047-1440-1-6.
21. M. Li, A. Tilles, J.M. Milwid, M. Hammad, J. Lee, M.L. Yarmush, B. Parekkadan “Phenotypic and Functional Characterization of Human Mesenchymal Stromal Cells in Hollow Fiber Bioreactors” Journal of Tissue Engineering and Regenerative Medicine (2012) 6(5) 369-377.
20. S.H. Jeong, J. Lee, D. Ge, K. Sun, T. Nakashima,S.l. Yoo, A. Agarwal, Y. Li, N.A. Kotov “Reversible Nanoparticle Gels with Colour Switching” Journal of Materials Chemistry (2011) 31(21), 11639-11643.
19. J. Lee, M.J. Cuddihy, G. Cater, N. A. Kotov “Engineering Liver Tissue Spheroids Using Inverted Colloidal Crystal Scaffolds” Biomaterials (2009) 30(27) 4687-4694.
18. J. Lee, D.G. Lilly, C.R. Doty, P. Podsiadlo, N.A. Kotov “In vitro Toxicity Testing of Nanoparticles in Three Dimensional Cell Culture” Small (2009) 5(10) 1213-1221.
(Research Highlights in Nature Nanotechnology)
17. J. Lee, N.A. Kotov “Notch Ligand Presenting Acellular 3D Microenvironments for Ex Vivo Human Hematopoietic Stem Cell Culture Made by Layer-by-Layer Assembly” Small (2009) 5(9) 1008-1013. (Front Cover Article)
16. P. Podsiadlo, M. Michel, K. Critchley, S. Srivastava, M. Qin, J. Lee, E. Verploegen, A.J. Hart, Y. Qi, and N.A. Kotov “Diffusional Self-Organization in Exponential Layer-by-Layer Films with Micro- and Nanoscale Periodicity” Angewandte Chemie (2009) 7;48(38) 7073-7077.
15. P. Podsiadlo, E.M. Arruda, E. Kheng, A.M. Waas, J. Lee, M. Qin, E. Chuang, A.K. Kaushik, H.S. Kim, S.T. Noh, N.A. Kotov “Layer-by-Layer Assembled Laminates with Hierarchical Organization from Nano- to Microscale: High-Toughness Nanomaterials and Deformation Imaging” ACS Nano (2009) 23;3(6) 1564-72.
14. J.E. Nichols, J. Cortiella, J. Lee, J.A. Niles, M. Cuddihy, S. Wang, S. Bynam, A. Cantu, R. Mlcak, E. Valdivia, R. Yancy, J. Bielitzki, M.L. McClure, N.A. Kotov “In vitro Analog of Human Bone Marrow from 3D Scaffolds with Biomimetic Inverted Colloidal Crystal Geometry” Biomaterials (2009) 30(6) 1071-1079.
(Highlighted in University of Michigan News, Economics, Daily Science)
13. Z. Tang, P. Podsiadlo, B. Shim, J. Lee, N.A. Kotov “The Effect of Stabilizer Density on Transformation of CdTe Nanoparticles Induced by Ag Cations” Advanced Functional Materials (2008) 18(23) 1-8.
12. P. Podsiadlo, M. Michel, J. Lee, N.W.S. Kam, V. Ball, J. Lee, Y. Qi, A.J. Hart, P.T. Hammond, N.A. Kotov, “Exponential Growth of Stratified LBL Films from Inorganic Sheets” Nano Letters (2008) 8 (6) 1762-1770.
11. S. Srivastava, V. Ball, P. Podsiadlo, J. Lee, P. Ho, N.A. Kotov, “Reversible Loading and Unloading of Semiconducting Nanoparticles in Exponential LBL Films” Journal of the American Chemical Society (2008) 130(12) 3748-3749.
10. J. Lee, M.J. Cuddihy, N.A. Kotov “3D Cell Culture Matrices: State of The Art” Tissue Engineering Part B: Review (2008) 14(1) 61-86.
(Most cited article)
9. P. Podsiadlo, V.A. Sinani, N.W.S. Kam, J. Hwan, J. Lee, N.A. Kotov “Gold Nanoparticles Enhance Anti-Leukemia Action of a Chemotherapeutic Agent”, Langmuir (2008) 24(2) 568-574.
(Front Cover Article)
8. G. Mehta, M.J. Kiel, J. Lee, N.A. Kotov, J.J. Linderman, S. Takayama “Polyelectrolyte-Clay-Protein Layer Films on Microfluidic PDMS Bioreactor Surfaces for Primary Murine Bone Marrow Culture” Advanced Functional Materials (2007) 17(15) 2701-2709.
7. J. Lee, P. Hernandez, J. Lee, A.O. Govorov, N.A. Kotov “Exciton-plasmon Interactions in Molecular Spring Assemblies of Nanowires and Wavelength-Based Protein Detection” Nature Materials (2007) 6(4) 291-295.
6. J. Lee, S. Shanbhag, N. Kotov “Inverted Colloidal Crystals Scaffolds as Three Dimensional Microenvironments for Cellular Co-cultures” Journal of Materials Chemistry (2006) 16(35), 3558-3564.
(Front Cover Article)
5. S. Shanbhag, J. Lee, N.A. Kotov “Diffusion in Three Dimensionally Ordered Scaffolds with Inverted Colloidal Crystal Geometry”, Biomaterials (2005) 26(27) 5581-5585.
4. Y. Liu, S. Wang, J. Lee, N.A. Kotov “A Floating Self-Assembly Route to Colloidal Crystal Templates for 3D Cell Scaffolds” Chemistry of Materials (2005) 17(20) 4918-4924.
3. P. Podsiadlo, S. Paternel, J.M. Rouillard, Z. Zhang, J. Lee, J. Lee, E. Gulari, N.A. Kotov “Layer-by-Layer Assembly of Nacre-like Nanostructured Composites with Antimicrobial Properties” Langmuir (2005) 21(25) 11915-11921.
2. P. Podsiadlo, S.Y. Choi, B. Shim, J. Lee, M. Cuddihy, N.A. Kotov “Molecularly Engineered Nanocomposites: Layer-by-Layer Assembly of Cellulose Nanocrystals” Biomacromolecules (2005) 6(6) 2914-2918.
1. S. Shanbhag, J. Lee, N.A. Kotov “Cell Scaffolds with Three-Dimensional Order: The Role of Modelling in Establishing Design Guidelines” Australian Journal of Chemistry (2005) 58(10) 713-715.