Mouse monoclonal
From Thermo Fisher:
Concentration: 1 mg/mL
Purification: Protein A
Storage buffer: PBS, pH 7.4, contains: 0.05% sodium azide
Storage conditions: -20°C or -80°C if preferred
Shipping conditions: Ambient (domestic); Wet ice (international)
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.