Sodium Valproate (Fisher 11474361)
Store powder at RT
Make 100 mM stock: 0.166g in 10 mL H2O
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| SKU | 02152064-CF |
| Alternate Names | 2-Propyl pentanoic acid; Valproic acid sodium salt; Sodium 2-propylpentanoate |
| Application Notes | Sodium Valproate is reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3α and GSK-3β. Valproic Acid has been reported to be a potent inhibitor of HDAC (histone deacetylase) in vitro (IC50 = 400 μM for HDAC1), thereby relieving HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase. This compound is also an inhibitor of the CYP2C9 enzyme. |
| Base Catalog Number | 152064 |
| Biochemical Physiological Actions | Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder. |
| Boiling Point | 219.5 deg C |
| CAS # | 1069-66-5 |
| Density | 0.904 g/cu cm at 25 deg C |
| EC Number | 213-961-8 |
| Format | Crystalline powder |
| Hazard Statements | H302 |
| Molecular Formula | C8H15NaO2 |
| Molecular Weight | 166.196 g/mol |
| Personal Protective Equipment | Dust mask , Eyeshields, Gloves |
| RTECS Number | YV7876000 |
| Safety Symbol | GHS07 |
| Solubility | In water, 2.0X10+3 mg/L at 20 deg C |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 8.47X10-2 mm Hg at 25 deg C (est) |