1. Raman V, Howell LM, Bloom SMK, Hall C, Wetherby V, Minter L, Kulkarni A, Forbes NS. 2023. Intracellular Salmonella delivery of an exogenous immunization antigen refocuses CD8 T cells against cancer cells, eliminates pancreatic tumors and forms antitumor immunity. Front Immunol. 14.
  2. Raman V, Deshpande C, Khanduja S, Howell LM, Van Dessel N, Forbes, NS. 2023. Build-a-bug workshop: Using microbial-host interactions and synthetic biology tools to create cancer therapies. Cell Host and Microbe. 31(10): 1574-1592.
  3. Bloom SMK, O’Hare N, Forbes NS. 2023. Bacterial delivery of therapeutic proteins to the nuclei of cancer cells. Biotechnology and Bioengineering. 120(5):1437-1448.
  4. Howell LM, Forbes NS. 2022. Bacteria-based immune therapies for cancer treatment. Seminar in Cancer Biology. 86(2):1163-1178.
  5. Sharma A, Raman V, Lee J, Forbes NS. 2022. Microbial Imbalance Induces Inflammation by Promoting Salmonella Penetration through the Mucosal Barrier. ACS Infectious Disease. 8(5):969-981.
  6. Raman V*, Van Dessel N*, Hall C, Wetherby V, Whitney S, Kolewe E, Bloom S, Sharma A, Hardy J, Bollen M, Van Eynde A, Forbes NS. 2021. Intracellular delivery of protein drugs with Salmonella designed to invade and autonomously lyse: a new tool to eliminate solid tumors. Nature Communications. 12:6116.
  7. Sharma A, Raman V, Lee J and Forbes NS. 2020. Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-a and IL-8 secretion. Biotechnol Bioeng. 117:2540-2555.
  8. Sharma A, Kwak JG, Kolewe KW, Schiffman JD, Forbes NS* and Lee J*. 2020. In vitro reconstitution of an intestinal mucus layer shows that cations and pH control the pore structure that regulates its permeability and barrier function. ACS Appl. Bio Mater. 3:2897–2909.
  9. Panteli JT, Van Dessel N, Forbes NS. 2020. Detection of tumors with fluoromarker-releasing bacteria. Int J Cancer. 146:137-149.
  10. Raman V, Van Dessel N, O’Connor OM, Forbes NS. 2019. The motility regulator flhDC drives intracellular accumulation and tumor colonization of Salmonella. J Immunother Cancer. 7:44.
  11. Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G. 2018. White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 6:78.
  12. Ganz DE, Sexton-Stallone B†, Brackett EL†, Forbes NS. 2018. Tissue transport affects how treatment scheduling increases the efficacy of chemotherapeutic drugs. J Theor Biol. 7:21-33.
  13. Panteli JT, Forbes NS. 2016. Engineered bacteria detect spatial profiles in glucose concentration within solid tumor cell masses. Biotechnol Bioeng. 113:2474-84.
  14. Brackett EL†, Swofford CA, Forbes NS. 2015. Microfluidic device to quantify the behavior of therapeutic bacteria in three-dimensional tumor tissue. In Bacterial Therapy of Cancer: Methods and Protocols. Ed. Robert Hoffman. Humana Press. 1409:35-48.
  15. Thornlow DN†, Brackett EL†, Gigas JM†, Van Dessel N, Forbes NS. 2015. Persistent enhancement of bacterial motility increases tumor penetration. Biotechnol Bioeng. 112: 2397- 2405.
  16. Panetli JT, Forkus B†, Forbes NS. 2015. Genetically modified bacteria to detect microscopic solid tumors: triggered release of a recombinant biomarker. Integr Biol. 7:423-434.
  17. Swofford CA, Van Dessel N, Forbes NS. 2015. Quorum-sensing Salmonella selectively trigger protein expression within tumors. PNAS. 112:3457-62.
  18. Zhang M, Forbes NS. 2015. Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating. J Control Release. 199:180-189.
    1. Cover article in the February 10th issue
  19. Van Dessel N, Swofford CA, Forbes NS. 2015. Potent and tumor specific: Arming bacteria with therapeutic proteins. Ther Deliv. 6:385-99.
  20. St. Jean AT, Swofford CA, Brentzel ZJ†, Jan Panteli, Forbes NS. 2014. Bacterial delivery of Staphylococcus aureus alpha-hemolysin causes regression and necrosis in murine tumors. Mol Ther. 22:1266-74.
  21. Kasinskas RW, Venkatasubramanian R, and Forbes NS. 2014. Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. Integr Biol. 6:399-410.
  22. Swofford CA, St. Jean AT, Panetli JT, Brentzel ZJ†, Forbes NS. 2014. Identification of Staphylococcus aureus ?-hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells. Biotechnol Bioeng. 111:1233-45.
  23. Zhang M, Swofford CA, Forbes NS. 2014. Lipid A controls the robustness of intratumoral accumulation of attenuated Salmonella in mice. Int J Cancer. 135:647-57.
  24. Toley BJ, Tropeano-Lovatt Z†, Harrington JL†, Forbes NS. 2013. Microfluidic technique to measure intratumoral transport and calculate drug efficacy shows that binding is essential for doxorubicin and release hampers Doxil. Integr. Biol. 5:1184-96
  25. Dai Y, Toley BJ, Swofford CA, Forbes NS. 2013. Construction of an inducible cell-communication system that amplifies Salmonella gene expression in tumor tissue. Biotechnol Bioeng. 110:1769-81
  26. Toley BJ, Forbes NS. 2012. Motility is critical for effective distribution and accumulation of bacteria in tumor tissue. Integr. Biol. 4:165-76
  27. Toley BJ, Park J, Kim BJ, Venkatasubramanian R, Maharbiz MM, Forbes NS. 2012. Micrometer-scale oxygen delivery rearranges cells and prevents necrosis in tumor tissue in vitro. Biotechnol Prog. 28:515-25
  28. Toley BJ, Ganz DE†, Walsh CL†, Forbes NS. 2011. Microfluidic device for recreating a tumor microenvironment in vitro. J Vis Exp. DOI: 10.3791/2425
  29. Ganai S,Arenas RB,Sauer JP†, Bentley B, Forbes NS. 2011. In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis. Cancer Gene Ther. 18:457-66
  30. Forbes NS. 2010. Engineering the perfect (bacterial) cancer therapy. Nat Rev Cancer. 10:785–794
  31. Venkatasubramanian R, Arenas RB, Henson MA, Forbes NS. 2010. Mechanistic modeling of dynamic MRI data predicts that tumor heterogeneity decreases therapeutic response. Br J Cancer. 103:486-97
  32. Kim BJ, Han G, Rotello VM, Forbes NS. 2010. Tuning payload delivery in tumor cylindroids using gold nanoparticles. Nat Nanotechnol. 5:465-72
  33. Hunnewell M†, Forbes NS. 2010. Active and inactive metabolic pathways in tumor spheroids: determination by GC-MS. Biotechnol Prog. 26:789-96
  34. Ganai S,Arenas RB,Forbes NS. 2009. Tumor-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice. Br J Cancer. 101:1683-91
  35. Walsh CL†, Babin BM†, Kasinskas RW, Foster JA†, McGarry MJ†, Forbes NS. 2009. A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab on a Chip. 9:545-554
  36. Ganai S, Arenas RB, Sauer JP, Bentley B, Forbes NS. 2009. Attenuated Salmonella typhimurium effectively targets breast cancer metastases. Annuls Surgical Onc. 16:18-19
  37. Venkatasubramanian R, Henson MA, Forbes NS. 2008. Incorporating cell cycle progression and drug penetration into metabolic models of multicellular tumor spheroid growth. Journal of Theoretical Biology. 253:98–117.
  38. Forbes NS. 2008. A module to foster engineering creativity: an interpolative design problem and an extrapolative research project. Chemical Engineering Education 42:166-172
  39. St. Jean A, Zhang M, Forbes NS. 2008. Bacterial therapies: completing the cancer treatment toolbox. Current Opinions in Biotechnology. 19:511-517
  40. Kim BJ, Forbes NS. 2008.Single cell sorting in cylindroids demonstrates how nutrient deprivation creates apoptotic and quiescent cell populations in tumors. Biotechnology and Bioengineering. 101:797-810
  41. Ganai S, Arenas RB, Sauer JP, Bentley B, Forbes NS. 2008. Tumor-targeting attenuated Salmonella typhimurium accumulates within therapeutically-resistant microenvironments adjacent to tumor necrosis. Journal of the American College of Surgeons 207: S101-S102
  42. Ganai S, Arenas RB, Forbes NS. 2008. Tumor-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival. Annals of Surgical Oncology. 15:64
  43. Kasinskas RW, Forbes NS. 2007. Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis. Cancer Res. 67:3201-9
  44. Kim BJ, Forbes NS. 2007. Flux analysis shows that hypoxia-inducible-factor-1-alpha minimally affects intracellular metabolism in tumor spheroids. Biotechnol Bioeng. 96:1167-82
  45. Ganai S, Arenas RB, Bentley B, Forbes NS. 2007. Targeting bacteriolytic therapy of solid tumors using Salmonella typhimurium. Annuls Surgical Oncology 14:71
  46. Forbes NS. 2006. Profile of a bacterial tumor killer. Nat. Biotech. 24:1484-1485
  47. Forbes NS, Meadows AL, Clark DS, Blanch HW. 2006. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metabolic Engineering. 8:639-652
  48. Venkatasubramanian R, Henson MA, Forbes NS. 2006. Incorporating energy metabolism into a growth model of multicellular tumor spheroids. J Theor Biol. 242:440-453
  49. Kasinskas RW, Forbes NS. 2006. Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro. Biotechnol Bioeng, 94:710-721
  50. Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. 2006. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 45:3165-3169
  51. Hong R, Han G, Fernandez JM, Kim BJ, Forbes NS, Rotello VM. 2006. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 128:1078-9
  52. Pinelis M, Kasinskas RW, BornoRT, ParkJH, Chu E, Forbes NS, Maharbiz MM. 2006. Microfluidic devices for the assembly and culture of three-dimensional multi-cellular constructs with diffusion-limited microenvironments. Proceedings of the 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (?TAS2006). Japan
  53. Han G, Hong R, Fernandez J, Kim BJ, Forbes NS, Rotello VM. 2006. Glutathione-mediated drug release using monolayer protected nanoparticle carriers. Abs Amer Chem Soc. 231:176
  54. Han G, You CC, Kim BJ, Forbes NS, Martin CT, Rotello VM. 2006. Light-regulated DNA transcription and delivery using photolabile gold nanoparticles. Abs Amer Chem Soc. 231:266
  55. Crichton MA, Forbes NS, Bhatia SR. 2005. USANS as a probe of large-scale structure in attractive colloidal glasses of block copolymer micelles.  MRS Symp. Proc. v. 840 – Neutron and X-Ray Scattering as Probes of Multiscale Phenomena. Q7.11.1-Q7.11.6
  56. Forbes NS, Munn LL, Fukumura D, Jain RK. 2003. Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 63:5188-5193
  57. Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. 2002. Acid production in variant, glycolysis-deficient and parental tumors in vivo: support for hypothesized tumor metabolism. Clin. Cancer Res. 8:1284-1291
  58. Jain RK, Forbes NS. 2001. Can engineered bacteria help control cancer? PNAS 98:14748-14750
  59. Forbes NS, Clark DS, Blanch HW. 2001. Using isotopomer path tracing to quantify metabolic fluxes in pathway models containing reversible reactions. Biotech. Bioeng. 74:196-211
  60. Forbes NS, Clark DS, Blanch HW. 2000. Analysis of metabolic fluxes in mammalian cells. Chap 4.4 in: Schügerl K, Bellgardt KH, editors. Bioreaction Engineering: Modeling and Control. Berlin: Springer Verlag
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