Stress management is important for everyone including mycobacteria. Mycobacteria must rearrange their life-building activities to respond to life-threatening situations. The Intracellular Membrane Domain (IMD) is an area of mycobacterial membrane, where many important life-building activities take place. In our new report published in mBio, we showed that the IMD dynamically rearranges its locations within the mycobacterial cell when the cells are exposed to stressful conditions such as antibiotic treatment. We propose that this IMD rearrangement is important for stress management.